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Common Chemotherapy Drugs and Side Effects

There are over 50 chemotherapy drugs that are commonly used. The following table gives examples of some chemotherapy drugs and their various names. It lists some of the cancer types but not necessarily all of the cancers for which they are used, and describes various side effects. Side effects may occur just after treatment (days or weeks) or they may occur later (months or years) after the chemotherapy has been given. The side effects list provided below do not comprise an all-inclusive list. Other side effects are possible.

As each person’s individual medical profile and diagnosis is different, so is his/her reaction to treatment. Side effects may be severe, mild, or absent. Be sure to discuss with your cancer care team any/all possible side effects of treatment before the treatment begins.

Chemotherapy Drug

Possible Side Effects
(Not all side effects are listed. Some of those listed may be short-term side effects; others are long-term side effects.)

carboplatin
(Paraplatin)
  • usually administered intravenously (IV) and used to treat lung, head and neck, and ovarian cancers
  • blood cell counts falling
    hair fall (reversible)
    confusion
    nausea, diarrhoea, and/or vomiting (usually a short-term side effect occurring the first 24 to 72 hours following treatment)
cisplatin
(Platinol, Platinol-AQ)
  • used to treat bladder, ovarian, and testicular malignancies, and typically administered intravenously (IV).
  • reduction in blood cell counts allergic reaction, which may include a rash and/or difficulty breathing nausea and vomiting that often lasts for 24 hours or longer changes in blood electrolytes kidney damage
cyclophosphamide
(Cytoxan, Neosar)
  • For the treatment of ovarian carcinoma, breast cancer, and lymphoma, it can be administered intravenously (IV) or orally.
  • blood cell counts falling
    nausea, vomiting, and stomach ache
    reduction in appetite
    hair fall (reversible)
    bladder injury
    fertility problems
    Heart or lung injury (with high doses)
    second-degree cancers (rare)
docetaxel
(Taxotere)
  • used to treat breast cancer, lung cancer, and prostate
  • blood cell counts falling
    nausea, vomiting, and stomach ache
    vomiting reduced appetite
    hair loss, a rash, and tingling and numbness in the hands and feet
doxorubicin
(Adriamycin)
  • used to treat multiple myeloma, lymphoma, and breast cancer when administered intravenously (IV)
  • blood cell counts falling
    gum disease hair loss
    vomiting and nauseous heart damage
erlotinib
(Tarceva)
  • used orally in the treatment of non-small cell lung cancer
  • Rash and other skin modifications
    diarrhea
etoposide
(VePesid)
  • used for lung, testicular, leukemia, and lymphoma cancers and can be administered intravenously (IV) or orally.
  • blood cell counts falling
    hair fall (reversible)
    vomiting and nauseous allergic reaction
    oral sores
    reduced blood pressure (during administration)
    reduction in appetite
    diarrhea and tummy ache
    Symptoms of the flu like bronchospasm
fluorouracil
(5-FU)
  • given intravenously (IV) and used to treat head and neck, colon, breast, and stomach cancers
  • blood cell counts falling
    stomachaches mouth sores
    photosensitivity
    arid skin
gemcitabine
(Gemzar)
  • given intravenously (IV) and used to treat lung, pancreatic, breast, and ovarian cancers
  • blood cell counts falling
    fever, symptoms of the flu, and nausea and vomiting
    rash
imatinib mesylate
(Gleevec)
  • used orally for gastrointestinal stromal tumor and chronic myelogenous leukemia (CML)
  • nauseous and dizzy
    fluid accumulation (swelling around ankles, eyes)
    muscular pain
    stomach bleeding, diarrhea, and rash
irinotecan
(Camptosar)
  • given intravenously (IV) and used to treat rectum and colon cancers
  • blood cell counts falling
    vomiting hair loss
methotrexate
(Folex, Mexate, Amethopterin)
  • breast, lung, blood, bone, and lymph system cancers may be treated using oral, intravenously (IV), intrathecally (into the spinal column), or a combination of these methods.
  • blood cell counts falling
    nauseous and dizzy
    oral sores
    rashes on the body and photosensitivity
    headache, grogginess, or sleepiness
    kidney injury
    liver injury
    hair fall
    seizures
paclitaxel
(Taxol, Abraxane)
  • given intravenously (IV) and used for lung, breast, and ovarian cancers
  • blood cell counts falling
    allergic response
    nauseous and dizzy
    reduced appetite
    altered taste, brittle or thin hair, and joint pain
    tingling or numbness in the fingers or toes
sorafinib
(Nexavar)
  • used for advanced kidney cancer and administered orally
  • blood pressure is high (during first few weeks of treatment)
    Other skin changes and a rash
    diarrheal ill health hair loss
    nauseous and dizzy
sunitinib
(Sutent)
  • administered orally and used for kidney cancer and gastrointestinal stromal tumors (GIST)
  • diarrhea, vomiting, and mouth ulcers
    stomach ache skin changes, such as a rash and skin discoloration fatigue
    blood pressure is high.
    bleeding, swelling, taste issues
topotecan
(Hycamtin)
  • used to treat lung and ovarian cancers when administered intravenously (IV)
  • blood cell counts falling
    vomiting hair loss
    nauseous and dizzy
vincristine
(Oncovin, Vincasar PFS)
  • typically administered intravenously (IV), used to treat lymphoma and leukemia
  • tingling or numbness in the fingers or toes
    weakness
    reduced reflexes
    jaw ache
    hair fall (reversible)
    stomach pain or indigestion
vinblastine
(Velban)
  • used to treat head and neck, testicular, and lymphoid malignancies when administered intravenously (IV)
  • blood cell counts falling
    hair fall
    abdominal pain or indigestion
    tingling or numbness in the fingers or toes and jaw pain

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